Laura Mechtouff, noelie Debs, carole Frindel, alexandre Bani-sadr, thomas Bochaton , alexandre Paccalet, claire Crola da silva, marielle Buisson, camille Amaz , yves Berthezene, omer faruk Eker , morgane Bouin, charles de Bourguignon, nathan Mewton, michel Ovize, gabriel Bidaux, norbert Nighoghossian, and Tae-Hee CHO. Association of blood biomarkers of inflammation with penumbra consumption after mechanical thrombectomy in patients with acute ischemic stroke. Neurology. In press

Stevic N, Maalouf J, Argaud L, Gallo-Bona N, Lo Grasso M, Gouriou Y, Gomez L, Crola Da Silva C, Ferrera R, Ovize M, Cour M, Bidaux G. Cooling Uncouples Differentially ROS Production from Respiration and Ca2+ Homeostasis Dynamic in Brain and Heart Mitochondria. Cells. 2022; 11(6):989.

Isnard F, Termoz A, Haesebaert J, Viprey M, Tazarourte K, Bravant E, Perreton N, Cakmak S, Meyran S, Ossedat C, Ducreux B, Pidoux C, Bony T, Douplat M, Potinet V, Sigal A, Derex L, Nighoghossian N, Schott-Pethelaz A, -M, Mechtouff L: Temporal Trend of Transient Ischemic Attack Management over a 10-Year Period: Data from the Rhône County, France. Cerebrovasc Dis 2022. doi: 10.1159/000520840

Chalet Lucie, Boutelier Timothé, Christen Thomas, Raguenes Dorian, Debatisse Justine, Eker Omer Faruk, Becker Guillaume, Nighoghossian Norbert, Cho Tae-Hee, Canet-Soulas Emmanuelle, Mechtouff Laura. Clinical Imaging of the Penumbra in Ischemic Stroke: From the Concept to the Era of Mechanical Thrombectomy. Front Cardiovasc Med. 2022 Mar 9;9:861913.

Mechtouff L, Nighoghossian N, Paccalet A, Crola Da Silva C, Leboube S, Buisson M, Mewton N, Amaz C, Varillon Y, Bonnefoy-Cudraz E, Rioufol G, Cho TH, Ovize M, Bidaux G, Bochaton T. Impact of age on systemic inflammatory profile of STEMI and acute ischemic stroke patients. Stroke. 2022

Dumot, C., Po, C., Capin, L. et al. Neurofunctional and neuroimaging readouts for designing a preclinical stem-cell therapy trial in experimental stroke. Sci Rep 12, 4700 (2022).

Bani-Sadr A, Cho T, Cappucci M, et al Assessment of three MR perfusion software packages in predicting final infarct volume after mechanical thrombectomy. J Neurointerv Surg. 2022 Mar 22; neurintsurg-2022-018674.

Nathan Mewton, François Roubille, Didier Bresson, Cyril Prieur, Claire Bouleti, Thomas Bochaton,  Fabrice Ivanes, Olivier Dubreuil, Loïc Biere, Ahmad Hayek, François Derimay, Mariama Akodad, Benjamin Alos, Lamis Haider, Naoual El Jonhy, Rachel Daw, Charles De Bourguignon, Carole Dhelens, Gérard Finet, Eric Bonnefoy-Cudraz, Gabriel Bidaux, Florent Boutitie, Delphine Maucort-Boulch, Pierre Croisille, Gilles Rioufol, Fabrice Prunier, Denis Angoulvant. Effect of Colchicine on Myocardial Injury in Acute Myocardial Infarction. Circulation. 2021 Sep 14; 144(11): 859–869.

Dia M, Paccalet A, Pillot B, Leon C, Ovize M, Crola Da Silva C, Bochaton T, Paillard M. Myocardial Ischemia-Reperfusion and Diabetes: Lessons Learned From Bedside to Bench. Front Cardiovasc Med. 2021 Mar 26;8:660698.

Mechtouff L, Sigovan M, Douek P, Costes N, Le Bars D, Mansuy A, Haesebaert J, Bani-Sadr A, Tordo J, Feugier P, Millon A, Luong S, Si-Mohamed S, Collet-Benzaquen D, Canet-Soulas E, Bochaton T, Crola Da Silva C, Paccalet A, Magne D, Berthezene Y, Nighoghossian N. Simultaneous assessment of microcalcifications and morphological criteria of vulnerability in carotid artery plaque using hybrid 18F-NaF PET/MRI. J Nucl Cardiol. 2020 Nov 3.

Mechtouff L, Rascle L, Crespy V, Canet-Soulas E, Nighoghossian N, Millon A. A narrative review of the pathophysiology of ischemic stroke in carotid plaques: a distinction versus a compromise between hemodynamic and embolic mechanism. Ann Transl Med. 2021 Jul;9(14):1208. 

Mechtouff L, Paccalet A, Crola Da Silva C et al. Prognosis value of serum soluble ST2 level in acute ischemic stroke and STEMI patients in the era of mechanical reperfusion therapy. J Neurol 269, 2641–2648 (2022).

Alexandre Paccalet, Claire Crola Da Silva, Laura Mechtouff, Camille Amaz, Yvonne Varillon, Charles de Bourguignon, Regine Cartier, Cyril Prieur, Danka Tomasevic, Nathalie Genot, Simon Leboube, François Derimay, Gilles Rioufol, Eric Bonnefoy-Cudraz, Nathan Mewton, Michel Ovize, Gabriel Bidaux, Thomas Bochaton. Serum Soluble Tumor Necrosis Factor Receptors 1 and 2 Are Early Prognosis Markers After ST-Segment Elevation Myocardial Infarction. Front Pharmacol. 2021 Sep 1;12:656928.

Bresson D, Roubille F, Prieur C, Biere L, Ivanes F, Bouleti C, Dubreuil O, Rioufol G, Boutitie F, Sideris G, Elbaz M, Bochaton T, De Bourguignon C, El Jonhy N, Dufay N, Dhelens C, Croisille P, Prunier F, Angoulvant D, Ovize M, Maucort-Boulch D, Mewton N: Colchicine for Left Ventricular Infarct Size Reduction in Acute Myocardial Infarction: A Phase II, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Study Protocol – The COVERT-MI Study. Cardiology 2021;146:151-160. doi: 10.1159/000512772

Hubert V, Hristovska I, Karpati S, Benkeder S, Dey A, Dumot C, Amaz C, Chounlamountri N, Watrin C, Comte JC, Chauveau F, Brun E, Marche P, Lerouge F, Parola S, Berthezène Y, Vorup-Jensen T, Pascual O, and Wiart M. Multimodal imaging with NanoGd reveals spatiotemporal features of neuroinflammation after experimental stroke. Adv Sci (Weinh). 2021 Jul 1;e2101433.

Nighoghossian N, Cho T, -H, Mechtouff L: Lenin’s Stroke. Case Rep Neurol 2021;13:384-387. doi: 10.1159/000515657

Bresson D, Roubille F, Prieur C, Biere L, Ivanes F, Bouleti C, Dubreuil O, Rioufol G, Boutitie F, Sideris G, Elbaz M, Bochaton T, De Bourguignon C, El Jonhy N, Dufay N, Dhelens C, Croisille P, Prunier F, Angoulvant D, Ovize M, Maucort-Boulch D, Mewton N: Colchicine for Left Ventricular Infarct Size Reduction in Acute Myocardial Infarction: A Phase II, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Study Protocol – The COVERT-MI Study. Cardiology 2021;146:151-160. doi: 10.1159/000512772

Clément Daviller, Timothé Boutelier, Shivraman Giri, Hélène Ratiney, Marie-pierre Jolly, Jean-Paul Vallée, Pierre Croisille and Magalie Viallon. Direct comparison of Bayesian and Fermi deconvolution approaches for myocardial blood flow quantification: in silico and clinical validations. Front Physiol. 2021 Apr 12;12:483714.

Vanessa Di Cataldo, Justine Debatisse, Joao Piraquive, Alain Géloën, Clément Grandin, Michaël Verset, Fabrice Taborik, Emmanuel Labaronne, Emmanuelle Loizon, Antoine Millon, Pauline Mury, Vincent Pialoux, André Serusclat, Franck Lamberton, Danielle Ibarrola, Franck Lavenne, Didier Le Bars, Thomas Troalen, Joachim Confais, Claire Crola Da Silva, Laura Mechtouff, Hugues Contamin, Zahi A Fayad, Emmanuelle Canet-Soulas, Cortical inflammation and brain signs of high-risk atherosclerosis in a non-human primate model, Brain Communications, Volume 3, Issue 2, 2021, fcab064,

Alhazmi, H., Bani-Sadr, A., Bochaton, T., Paccalet, A., Da Silva, C.C., Buisson, M., Amaz, C., Ameli, R., Berthezene, Y., Eker, O.F., Ovize, M., Cho, T.-H., Nighoghossian, N. and Mechtouff, L. (2021), Large vessel cardioembolic stroke and embolic stroke of undetermined source share a common profile of matrix metalloproteinase-9 level and susceptibility vessel sign length. Eur J Neurol, 28: 1977-1983.

Hayek, A, Paccalet, A, Mechtouff, L, et al. Kinetics and prognostic value of soluble VCAM-1 in ST-segment elevation myocardial infarction patients. Immun Inflamm Dis. 2021; 9: 493– 501.

Kévin Moulin, Pierre Croisille, Magalie Viallon, Ilya A Verzhbinsky, Luigi E Perotti, Daniel B Ennis. Myofiber strain in healthy humans using DENSE and cDTI. Magn Reson Med. 2021 Jul;86(1):277-292.

Antoine Anfray, Camille Brodin, Antoine Drieu, Fanny Potzeha, Basile Dalarun, Véronique Agin, Denis Vivien, Cyrille Orset. Single- and two- chain tissue type plasminogen activator treatments differentially influence cerebral recovery after stroke. Exp Neurol. 2021 Apr;338:113606.

Martin Cour, Camille Amaz, Julien Bohé, Thomas Rimmelé, Michel Ovize, Laurent Argaud. Day-90 survival in critically-ill patients with COVID-19 and hydroxychloroquine: A propensity analysis. Ann Transl Med 2021.

Bochaton T, Lassus J, Paccalet A, Derimay F, Rioufol G, Prieur C, Bonnefoy-Cudraz E, Crola Da Silva C, Bernelin H, Amaz C, Espanet S, de Bourguignon C, Dufay N, Cartier R, Croisille P, Ovize M, Mewton N. Association of myocardial hemorrhage and persistent microvascular obstruction with circulating inflammatory biomarkers in STEMI patients. PLoS One. 2021 Jan 28;16(1):e0245684.

Schott, A.M., Termoz, A., Viprey, M. et al. Short and long-term impact of four sets of actions on acute ischemic stroke management in Rhône County, a population based before-and-after prospective study. BMC Health Serv Res 21, 12 (2021).

Noëlie Debs, Tae-Hee Cho, David Rousseau, Yves Berthezène, Marielle Buisson, Omer Eker, Laura Mechtouff, Norbert Nighoghossian, Michel Ovize, Carole Frindel. Impact of the reperfusion status for predicting the final stroke infarct using deep learning. Neuroimage Clin. 2021;29:102548.

Barral, M., Rabier, H., Termoz, A., Serrier, H., Colin, C., Haesebaert, J., Derex, L., Nighoghossian, N., Schott, A.-M., Viprey, M. and (2021), Patients' productivity losses and informal care costs related to ischemic stroke: a French population-based study. Eur J Neurol, 28: 548-557.

Viprey M, Gouillet M, Puppo C, Termoz A, Della Vecchia C, Derex L, Haesebaert J, Schott AM, Préau M. A Qualitative Study of Barriers and Facilitators to Adherence to Secondary Prevention Medications Among French Patients Suffering from Stroke and Transient Ischemic Attack. Patient Prefer Adherence. 2020 Jul 21;14:1213-1223.

François Sauer, Laurence Jesel, Benjamin Marchandot, François Derimay, Thomas Bochaton, Camille Amaz, François Roubille, Guillaume Cayla, Gilles Rioufol, David Garcia-Dorado, Marc Claeys, Denis Angoulvant, Eric Bonnefoy-Cudraz, Patrice Guérin, Annie Trinh, Kensuke Matsushita, Patrick Ohlmann, Claire Jossan, Nathan Mewton, Michel Ovize, Olivier Morel. Life-threatening arrhythmias in anterior ST-segment elevation myocardial infarction patients treated by percutaneous coronary intervention: adverse impact of morphine. Eur Heart J Acute Cardiovasc Care. 2020 Oct 14;zuaa005.


Laura Mechtouff, Thomas Bochaton, Alexandre Paccalet, Claire Crola Da Silva, Marielle Buisson, Camille Amaz, Laurent Derex, Elodie Ong, Yves Berthezene, Omer Faruk Eker, Nathalie Dufay, Nathan Mewton, Michel Ovize, Tae-Hee Cho, Norbert Nighoghossian,  Neurology, Feb 2021, 96 (5) e752-e757; DOI: 10.1212/WNL.0000000000011268

Justine Debatisse, Omer Faruk Eker, Océane Wateau, Tae-Hee Cho, Marlène Wiart, David Ramonet, Nicolas Costes, Inés Mérida, Christelle Léon, Maya Dia, Mélanie Paillard, Joachim Confais, Fabien Rossetti, Jean-Baptiste Langlois, Thomas Troalen, Thibaut Iecker, Didier Le Bars, Sophie Lancelot, Baptiste Bouchier, Anne-Claire Lukasziewicz, Adrien Oudotte, Norbert Nighoghossian, Michel Ovize, Hugues Contamin, François Lux, Olivier Tillement, Emmanuelle Canet-Soulas, PET-MRI nanoparticles imaging of blood–brain barrier damage and modulation after stroke reperfusion, Brain Communications, Volume 2, Issue 2, 2020, fcaa193,

Rabier H, Serrier H, Schott ., Mewton N, Margier J, Barral M, Colin, C. (2020). Myocardial infarction: Economic, health, and social impacts on informal caregivers. International Journal of Technology Assessment in Health Care, 36(3), 245-251. doi:10.1017/S0266462320000148

Gouriou Y, Alam MR, Harhous Z, Da Silva CC, Baetz D, Badawi S, Lefai E, Rieusset J, Durand A, Harisseh R, Gharib A, Ovize M, Bidaux G. ANT2-Mediated ATP Import into Mitochondria Protects against Hypoxia Lethal Injury. Cells. 2020; 9(12):2542.



Basalay, M.V., Wiart, M., Chauveau, F. et al. Neuroprotection by remote ischemic conditioning in the setting of acute ischemic stroke: a preclinical two-centre study. Sci Rep 10, 16874 (2020).

Debatisse J, Wateau O, Cho T-H, et al. A non-human primate model of stroke reproducing endovascular thrombectomy and allowing long-term imaging and neurological read-outs. Journal of Cerebral Blood Flow & Metabolism. 2021;41(4):745-760. doi:10.1177/0271678X20921310

Choice of Initial Brain Imaging in Patients with Suspected Acute Stroke: STROKE69, a Population-Based Study. Cerebrovasc Dis. March 2020.

Matrix Metalloproteinase-9 Relationship With Infarct Growth and Hemorrhagic Transformation in the Era of Thrombectomy. Frontiers in Neurology. June 2020.

Matrix Metalloproteinase-9 and Monocyte Chemoattractant Protein-1 Are Associated With Collateral Status in Acute Ischemic Stroke With Large Vessel Occlusion. Stroke. June 2020.

Moulin K, Viallon M, Romero W, Chazot A, Mewton N, Isaaz K, P Croisille. MRI of Reperfused Acute Myocardial Infarction Edema: ADC Quantification versus T1 and T2 Mapping. Radiology. March 2020.

An innovative sequence of hypoxia-reoxygenation on adult mouse cardiomyocytes in suspension to perform multilabeling analysis by flow cytometry. Methods in Cell Physiology. February 2020.

Heat Shock Protein 70 as a Biomarker of Clinical Outcomes After STEMI. J Am Coll Cardiol. January 2020. 

, , , , , . . NMR in Biomedicine. .

, , , , . . Br J Pharmacol. 20 August .

Drieu A, Buendia I, Levard D et al. Immune Response and Anti-inflammatory Strategies in a Clinically Relevant Model of Thromboembolic Ischemic Stroke with Reperfusion. Transl. Stroke Res. 14 September 2019.

Hubert V, Dumot C, Ong E, Amaz C, Canet-Soulas E, Chauveau F, Wiart M. MRI coupled with clinically-applicable iron oxide nanoparticles reveals choroid plexus involvement in a murine model of neuroinflammation. Scientific reports. 11 July 2019. 

Nighoghossian N, Cornut L, Amaz C, Eker O, Mewton N, Ameli R, Berner LP, Cho TH, Ovize M, Berthezene Y. Impact of collateral status on neuroprotective effect of cyclosporine A in acute ischemic stroke. Current Neurovascular Research. June 2019

Clayes MJ, Coussement P, Dubois P, Garcia-Dorado D, Mewton N, Amaz C, Ovize M. Clinical effects of cyclosporine in acute anterior myocardial infarction complicated by heart failure: A subgroup analysis of the CIRCUS Trial. American Heart Journal. 30 may 2019  

Eker OF, Rascle L, Cho TH, Mechtouff L, Derex L, Ong E, Berthezene Y, Nighoghossian N. Does small vessel disease burden impact collateral circulation in ischemic stroke treated by mechanical thrombectomy? Stroke. 30 avril 2019.

Beringer A, Gouriou Y, Lavocat F, Ovize M, Miossec P. Blockade of Store-Operated Calcium Entry Reduces IL-17/TNF Cytokine-Induced Inflammatory Response in Human Myoblasts. Frontiers in Immunology. 14 January 2019 

Davidson SM, Ferdinandy P, Andreadou I, Bøtker HE, Heusch G, Ibáñez B, et al. Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury. Journal of the American College of Cardiology. January 2019

Hubert V, Chauveau F, Dumot C, Ong E, Berner L-P, Canet-Soulas E, Ghersi-Egea J-B, et Wiart M. Clinical Imaging of Choroid Plexus in Health and in Brain Disorders: A Mini-Review. Frontiers in Molecular Neuroscience. 12 February 2019.

Davidson SM, Arjun S, Basalay MV, Bell RM, Bromage DL, Bøtker HE, Carr RD, Cunningham J, Ghosh AK, Heusch G, Ibanez B, Kleinbongard P, Lecour S, Maddock H, Ovize M, Walker M, Wiart M, Yellon DM. The 10th Biennial Hatter Cardiovascular Institute workshop: cellular protection—evaluating new directions in the setting of myocardial infarction, ischaemic stroke, and cardio-oncology. Basic Research in Cardiology. November 2018 

Gaubert M,, Fournier AP, Docagne F, Vivien D, Martinez de Lizarrondo S. Molecular Magnetic Resonance Imaging of Endothelial Activation in the Central Nervous System. Theranostics. 2 February 2018 
Viannay L, Haesebaert J, Florin F, Riva R, Mechtouff L, Gory B, Ong E, Labeyrie P-E, Derex L, Hermier M, Chamard L, Berner L-P, Ameli R, Berthezène Y, Turjman F, Nighoghossian N, Cho TH . Impact of the Thrombectomy Trials on the Management and Outcome of Large Vessel Stroke: Data From the Lyon Stroke Center. Frontiers in Neurology. 28 August 2018

Bourezg A, Bochaton T, Mewton N, Morel O, Cayla G, Rioufol G, Bonnefoy-Cudraz E, Guerin P, Elbaz M, Boussaha I, Amaz C, Angoulvant D, Ovize M, Circus Investiagtors. Atrial Fibrillation, Intra-Ventricular Thrombus, and Other Anticoagulant Indications Relationship with Adverse Outcomes in Acute Anterior Myocardial Infarction Patients. Journal of Cardiology. October 2018

Bernelin H, Mewton N, Si‐Mohamed S, Croisille P, Rioufol G, Bonnefoy‐Cudraz E, Douek P, Dufay N, Amaz C, Jossan C, Ovize M, Bochaton T. Neprilysin Levels at the Acute Phase of ST-Elevation Myocardial Infarction. Clinical Cardiology, 3 octobre 2018.

 Hrifach, A., Ganne, C., Couray-Targe, S. et al. National cost study versus hospital cost accounting for organ recovery cost assessment in a French hospital group. Cost Eff Resour Alloc 16, 34 (2018).