CREATIS is a joint biomedical imaging research facility (CNRS UMR 5220 – INSERM U1206 – Université Lyon 1 – INSA Lyon - Université Jean Monnet Saint-Etienne). CREATIS gathers together about 200 scientists from Computer Science, Engineering, Physics, and clinical investigators from Cardiology, Neurology, and Radiology. CREATIS researchers provide specialized expertise in image acquisition and image post-processing for different modalities such as computerized tomography (CT), magbetic resonance imaging (MRI), and ultrasound (US), with a focus on two fundamental problems, namely:

- Identification of major health issues that can be addressed by imaging,

- Identification of theoretical barriers in biomedical imaging related to signal and image processing, modeling and numerical simulation.

The « Stroke & Diagnostic NeuroImaging » team:

The team nested in CREATIS lab is a biomedical imaging research team including neurologist, radiologist and post processing researcher involved in stroke imaging analysis.

In this project, the team will examine the safety of the clinical application of a new MRI post-processing software (here called « optimized MR »: OMR) developed during the MARVELOUS program. The new software will allow to implement new strategies pre- or post-treatment in ischemic stroke whose safety will be examined here in a prospective safety trial. This trial will use the software test layout (first version) of Olea Medical that is scheduled for mid-term through the MARVELOUS program. The main objective is to assess if OMR may improve evaluation of ischemic core, penumbra, collateral circulation and blood-brain barrier permeability.

The « NMR and Optics: Methods and Systems » team:

Team 5 (NMR and Optics: Methods and systems) and Info Dev’ will mainly be involved in the project.  The skills of the involved researchers are mainly in MR and US Imaging, especially cardiac imaging with a clear focus toward heart ischemic disease.

In this project, CREATIS will be involved in the development of non-invasive MR based biomarkers using routine and more advanced quantitative MR protocols. The main tasks will be to implement, validate deploy and valorise dedicated MR Imaging and protocols.

CREATIS would also be involved in the implementation and transfer of the methodological and experimental laboratory research output into experimental validation.

The team members working on the MARVELOUS project are Yves Berthezène, Frederic Cervenansky, Tae-Hee Cho, Pierre Croisille, Carole Frindel, Nikolaos Makris, Norbert Nighoghossian, David Rousseau and Magalie Viallon.